Structure of PDB 6qdv Chain 7

Receptor sequence
>6qdv7 (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
DMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQ
IIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQ
IQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMI
RRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATL
PHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDL
YDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMK
EFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRY
GRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
3D structure
PDB6qdv A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Chain7
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP 7 F58 Q65 G85 T86 G87 K88 T89 G340 D342 R367 R370 Y371 F37 Q44 G64 T65 G66 K67 T68 G319 D321 R346 R349 Y350
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008143 poly(A) binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0035368 selenocysteine insertion sequence binding
GO:0035613 RNA stem-loop binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000398 mRNA splicing, via spliceosome
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0008306 associative learning
GO:0008380 RNA splicing
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0017148 negative regulation of translation
GO:0035640 exploration behavior
GO:0045727 positive regulation of translation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0051028 mRNA transport
GO:0072715 cellular response to selenite ion
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission
GO:1904570 negative regulation of selenocysteine incorporation
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0030425 dendrite
GO:0035145 exon-exon junction complex
GO:0043025 neuronal cell body
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6qdv, PDBe:6qdv, PDBj:6qdv
PDBsum6qdv
PubMed30705154
UniProtP38919|IF4A3_HUMAN Eukaryotic initiation factor 4A-III (Gene Name=EIF4A3)

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