Structure of PDB 5jbh Chain 7

Receptor sequence
>5jbh7 (length=409) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence]
QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNI
GVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLS
GAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSK
EEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPY
RDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVL
PGLRVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLT
KADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKET
LMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWR
MIGWGLVEI
3D structure
PDB5jbh Cryo-EM study of start codon selection during archaeal translation initiation.
Chain7
Resolution5.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K22 T23 T46 H97
Catalytic site (residue number reindexed from 1) K16 T17 T40 H91
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 7 V223 P226 S278 R280 A296 V217 P220 S272 R274 A290
BS02 MET 7 Y51 R219 F281 G282 Y45 R213 F275 G276
BS03 MG 7 T23 K36 T46 T17 K30 T40
BS04 GNP 7 V18 D19 G21 K22 T23 T24 K36 M45 G96 N149 K150 D152 L186 V12 D13 G15 K16 T17 T18 K30 M39 G90 N143 K144 D146 L180
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation

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Molecular Function
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Biological Process
External links
PDB RCSB:5jbh, PDBe:5jbh, PDBj:5jbh
PDBsum5jbh
PubMed27819266
UniProtQ980A5|IF2G_SACS2 Translation initiation factor 2 subunit gamma (Gene Name=eif2g)

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