Structure of PDB 8p63 Chain 6

Receptor sequence
>8p636 (length=636) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
LNHVKKVDDVTGEKVREAFEQFLEDFSVQSTDTGEVEKVYRAQIEFMKIY
DLNTIYIDYQHLSMRENGALAMAISEQYYRFLPFLQKGLRRVVRKYAPEL
LNERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEVRPELYKA
SFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQ
KVRIQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDV
TQLGLPGVKKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGDQEVF
LNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGHEAVKKGILLQMLGG
VHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSGKASS
AAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHE
AMEQQTISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAP
IMSRFDLFFVILDDCNEKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRY
IKYARTFKPILTKEARSYLVEKYKELRKDDAQGFSRSSYRITVRQLESMI
RLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
3D structure
PDB8p63 Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Chain6
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 6 R614 K665 A666 R410 K461 A462
BS02 ATP 6 E657 R708 R798 E453 R504 R594
BS03 ADP 6 V537 F538 S578 S580 K581 S582 V333 F334 S374 S376 K377 S378
BS04 ZN 6 C311 C333 C338 C154 C176 C181
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:1902969 mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p63, PDBe:8p63, PDBj:8p63
PDBsum8p63
PubMed38760633
UniProtP53091|MCM6_YEAST DNA replication licensing factor MCM6 (Gene Name=MCM6)

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