Structure of PDB 7w1y Chain 6

Receptor sequence
>7w1y6 (length=716) Species: 9606 (Homo sapiens) [Search protein sequence]
HLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVS
FVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAF
QDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTV
IRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAE
LPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARA
ETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKE
LEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRG
VLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAV
YTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDV
RDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLK
QNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVY
SLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRIT
VRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPFSEYC
RISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKR
IIEKVIHRLTHYDHVL
3D structure
PDB7w1y The human pre-replication complex is an open complex.
Chain6
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 6 R285 R435 R271 R418
BS02 ATP 6 R619 E622 R602 E605
BS03 ZN 6 C158 C161 C180 C185 C144 C147 C166 C171
BS04 ADP 6 H359 S399 T400 A401 K402 S403 Q404 H342 S382 T383 A384 K385 S386 Q387
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902969 mitotic DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtQ14566|MCM6_HUMAN DNA replication licensing factor MCM6 (Gene Name=MCM6)

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