Structure of PDB 6rax Chain 6

Receptor sequence
>6rax6 (length=628) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
VKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDV
EKYDQNLATAIIEEYYHIYPFLCQSVSNYVKDRIGLKTQKDCYVAFTEVP
TRHKVRDLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNV
EQQFKFTNPTICRNPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRG
CIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLAGVGTRAENSS
RHKPGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDMKKQMTDAE
WHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEK
TSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAV
VRDEESFDFVIEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTIS
IARAGVRATLNARTSILAAANPINGRYDRSKSLQQNIQLSAPIMSRFDLF
FILVDECNEVVDYAIARKIVDLHSNIEESVERAYTREEVLRYVTFARQFK
PVISQEAGHMLVENYGHLRQRDTGTSGRSTWRITVRQLESMIRLSEAMAK
LECSNRVLERHVKEAFRLLNKSIIRVEQ
3D structure
PDB6rax Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain6
Resolution3.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP 6 E470 Q471 R611 E445 Q446 R586
BS02 ADP 6 Y351 P390 S391 T392 A393 S395 Y326 P365 S366 T367 A368 S370
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0007307 eggshell chorion gene amplification
GO:0032508 DNA duplex unwinding
GO:0051301 cell division
GO:1902969 mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rax, PDBe:6rax, PDBj:6rax
PDBsum6rax
PubMed31484077
UniProtQ9V461|MCM6_DROME DNA replication licensing factor Mcm6 (Gene Name=Mcm6)

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