Structure of PDB 5z57 Chain 6

Receptor sequence
>5z576 (length=89) Species: 9606 (Homo sapiens) [Search protein sequence]
DLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQG
RCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSK
3D structure
PDB5z57 Structure of the human activated spliceosome in three conformational states.
Chain6
Resolution6.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 6 K25 C26 C61 K19 C20 C55
BS02 ZN 6 K13 C49 K7 C43
BS03 ZN 6 C33 C75 C27 C69
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome

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Cellular Component
External links
PDB RCSB:5z57, PDBe:5z57, PDBj:5z57
PDBsum5z57
PubMed29360106
UniProtQ7RTV0|PHF5A_HUMAN PHD finger-like domain-containing protein 5A (Gene Name=PHF5A)

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