Structure of PDB 6qw6 Chain 5X

Receptor sequence
>6qw65X (length=583) Species: 9606 (Homo sapiens) [Search protein sequence]
EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKDKS
KELHAIKERYLRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGID
LKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWS
QKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDK
CGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPK
IDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISR
EDQGFRLRMGEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGF
EPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATM
PPAVERLARSYLRRPAVVYIGAGKPHERVEQKVFLMSESEKRKKLLAILE
QGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLREFALSNLKAGAKDIL
VATDVIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKED
SAVFYELKQAILESPVSSPPELANHPDAQHKPG
3D structure
PDB6qw6 Mechanism of 5' splice site transfer for human spliceosome activation.
Chain5X
Resolution2.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 5X K271 F272 K63 F64
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0062176 R-loop processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6qw6, PDBe:6qw6, PDBj:6qw6
PDBsum6qw6
PubMed30975767
UniProtQ9BUQ8|DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (Gene Name=DDX23)

[Back to BioLiP]