Structure of PDB 8h6j Chain 5C

Receptor sequence
>8h6j5C (length=852) Species: 9606 (Homo sapiens) [Search protein sequence]
MEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTH
PEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMD
TPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVT
VCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLL
GNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTR
KFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLT
KEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYT
GGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAG
QPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEG
VDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKML
DGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIK
VADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEV
VQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEV
DKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRG
GGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRR
GHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHW
QIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFD
DP
3D structure
PDB8h6j Atomic structures of human exon-defined spliceosome prior to activation.
Chain5C
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG 5C T143 D169 T39 D65
BS02 GTP 5C H139 G141 K142 T143 G180 G207 K259 D261 S311 S312 Q313 H35 G37 K38 T39 G76 G103 K155 D157 S207 S208 Q209
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042220 response to cocaine
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6j, PDBe:8h6j, PDBj:8h6j
PDBsum8h6j
PubMed38658629
UniProtQ15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (Gene Name=EFTUD2)

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