Structure of PDB 8p62 Chain 5

Receptor sequence
>8p625 (length=693) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLI
GYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQLLNSLPTFQLI
LNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRH
TTSITINNFNSITGNTVSLPRSCLSKNCGPDPYIIIHESSKFIDQQFLKL
QEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNSKNGSG
VAIRTPYIKILGIQSDVETSSVTMFTEEEEEEFLQLSRNPKLYEILTNSI
APSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQ
LLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADG
GVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAAN
PIYGRYDDLKSPGDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVIN
IHTGNANAMQNQQEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSS
NFVTIRKQLLINELESTERSSIPITIRQLEAIIRITESLAKLELSPIAQE
RHVDEAIRLFQASTMDAASQDPIGGTSLSEIRRFEQELKRRLPIGWSTSY
QTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRS
3D structure
PDB8p62 Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Chain5
Resolution3.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 5 S445 R455 F462 K506 S371 R381 F388 K432
BS02 ATP 5 E498 R549 R651 E424 R475 R577
BS03 ATP 5 F379 G419 T420 A421 K422 S423 Q424 F305 G345 T346 A347 K348 S349 Q350
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p62, PDBe:8p62, PDBj:8p62
PDBsum8p62
PubMed38760633
UniProtP29496|MCM5_YEAST Minichromosome maintenance protein 5 (Gene Name=MCM5)

[Back to BioLiP]