Structure of PDB 7pt6 Chain 5

Receptor sequence
>7pt65 (length=644) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
SFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLR
NNILVKNYSLTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRI
SILSRAQSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLS
SRATYLSIMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTNCGPDPYII
IHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVT
IVGIYSIYNSGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEE
FLQLSRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRL
RGDINVLLLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRD
PMTREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAK
AGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNIDFQTTILSRFDMIFIV
KDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMKRYITYC
RLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAI
IRITESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGL
3D structure
PDB7pt6 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
Chain5
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP 5 E498 R651 E654 E442 R595 E598
BS02 AGS 5 I378 F379 G419 T420 A421 K422 S423 Q424 I322 F323 G363 T364 A365 K366 S367 Q368
BS03 ZN 5 C183 C186 C211 C236 C160 C163 C188 C193
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pt6, PDBe:7pt6, PDBj:7pt6
PDBsum7pt6
PubMed35614055
UniProtP29496|MCM5_YEAST Minichromosome maintenance protein 5 (Gene Name=MCM5)

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