Structure of PDB 7plo Chain 5

Receptor sequence
>7plo5 (length=614) Species: 9606 (Homo sapiens) [Search protein sequence]
ADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWI
EVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISI
QCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCK
CVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYS
IKKFVGVGIRSSYIRVLGIQVDTGAVSPQEEEEFRRLAALPNVYEVISKS
IAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKS
QLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLAD
GGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAA
NSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVIT
LHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYII
MRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVE
EALRLFQVSTLDAA
3D structure
PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Chain5
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 5 S410 S417 V418 R420 F427 K471 A472 S372 S379 V380 R382 F389 K433 A434
BS02 ANP 5 R371 R513 R611 E614 R333 R475 R573 E576
BS03 ANP 5 F344 G384 T385 A386 K387 S388 Q389 N489 L532 F306 G346 T347 A348 K349 S350 Q351 N451 L494
BS04 ZN 5 C172 C197 C152 C177
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtP33992|MCM5_HUMAN DNA replication licensing factor MCM5 (Gene Name=MCM5)

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