Structure of PDB 7of5 Chain 5

Receptor sequence

>7of55 (length=392) Species: 9606 (Homo sapiens)

YEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDR
GYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLIE
GLPEKVLSLVDDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPVI
VDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESLLLQVRGSGGARL
STKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGFQ
EGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLYG
NDAKVLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSDQ
LLYQHFWCLPVIKKRVVVEPVGPVGFKPETFRKFLALYLHGA

3D structure

• PDB: 7of5 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Chain: 5
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	5	Y31 E32 W33 G34 V35 R36 S37 F66 P68 W78 R80 K83 P85 R86 F87 Y88 R89 S90 L93 H96 L98 H108 H109 R110 I170 R173 R223 H266 C268 I270 L299 R300 P301 H302 Q305 Q384 H385 W387 C388 L389 K394 R395	Y1 E2 W3 G4 V5 R6 S7 F36 P38 W48 R50 K53 P55 R56 F57 Y58 R59 S60 L63 H66 L68 H78 H79 R80 I140 R143 R193 H236 C238 I240 L269 R270 P271 H272 Q275 Q354 H355 W357 C358 L359 K364 R365

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of5, PDBe:7of5, PDBj:7of5
• PDBsum: 7of5
• PubMed: 34135319
• UniProt: Q9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)