Structure of PDB 6rqc Chain 5

Receptor sequence
>6rqc5 (length=602) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYSLTVNMEHLIGYN
EDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANSLPTFQLILNS
NANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLSIMCRNCRHTTS
ITINNFNTVSLPRSCNCGPDPYIIIHESSKFIDQQFLKLQEIPELVPVGE
MPRNLTMTCDRYLTNKVIPGTRVTIVGIYSIYNGVAIRTPYIKILGIQSD
VETSSIWNSVTMFTEEEEEEFLQLSRNPKLYEILTNSIAPSIFGNEDIKK
AIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVSPIA
VYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCIDEFDKMR
DEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSP
GDNIDFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQ
QEENGSEISIEKMKRYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLIN
ELESTPITIRQLEAIIRITESLAKLELSPIAQERHVDEAIRLFQASTMDA
AS
3D structure
PDB6rqc Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
Chain5
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 5 R209 R486 R163 R400
BS02 ADP 5 R549 I650 R651 R463 I559 R560
BS03 ADP 5 G419 A421 K422 S423 Q424 I568 G333 A335 K336 S337 Q338 I482
BS04 ZN 5 C183 C211 C142 C165
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0006368 transcription elongation by RNA polymerase II
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0031507 heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rqc, PDBe:6rqc, PDBj:6rqc
PDBsum6rqc
PubMed31748745
UniProtP29496|MCM5_YEAST Minichromosome maintenance protein 5 (Gene Name=MCM5)

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