Structure of PDB 6rax Chain 5

Receptor sequence
>6rax5 (length=620) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
NQQDAQINLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIE
MEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHD
IQILLSSNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCL
SCSTVIPNLYALPRKCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQE
LPDFVPQGEIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRD
GREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAASG
DIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLL
LGDPGTAKSQLLKFVEKVPIAVYTSGKGSSTASVMKDPQTRNFVMEGAMV
LADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVL
AAANSIFGRWDDTKGEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKH
IINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEKLK
SRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFAT
DEHVNEALRLFQVSTLDAAM
3D structure
PDB6rax Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain5
Resolution3.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 5 T412 V415 K417 R422 T381 V384 K386 R391
BS02 ATP 5 V609 R610 V577 R578
BS03 ATP 5 P380 G381 T382 A383 K384 S385 Q386 L529 P354 G355 T356 A357 K358 S359 Q360 L497
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0030261 chromosome condensation
GO:0032508 DNA duplex unwinding
GO:0042023 DNA endoreduplication
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rax, PDBe:6rax, PDBj:6rax
PDBsum6rax
PubMed31484077
UniProtQ9VGW6|MCM5_DROME DNA replication licensing factor Mcm5 (Gene Name=Mcm5)

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