Structure of PDB 6raw Chain 5

Receptor sequence
>6raw5 (length=576) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
INLQAVKKKYKEFIRTFNEENFFYKYRDTLKRNYLNGRYFLEIEMEDLVG
FDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLS
SNANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSYALPRKCNPK
CPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCER
VVPGNRVLIQGIYSIRKGVRAPYMRVVGITVDSEGAGAISRYSNITSDEE
EHFRRMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGL
CRRGDINVLLLGDPGTAKSQLLKFVEKVPIAVYTSGKGGLTASVMKDPQT
RNFVMEGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGIT
TTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMIFIVKDIHD
ESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPR
LSEAAGEKLKSRYVLMRSGAGQQEKASDKRITVRQLEAVIRISESLAKIR
LQPFATDEHVNEALRLFQVSTLDAAM
3D structure
PDB6raw Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain5
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 5 R190 L204 T412 V415 R422 F424 K468 R145 L153 T341 V344 R351 F353 K396
BS02 ATP 5 I340 P380 T382 A383 K384 S385 Q386 I533 I274 P314 T316 A317 K318 S319 Q320 I461
BS03 ATP 5 R510 V609 R610 R438 V533 R534
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0030261 chromosome condensation
GO:0032508 DNA duplex unwinding
GO:0042023 DNA endoreduplication
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0042555 MCM complex
GO:0043231 intracellular membrane-bounded organelle
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raw, PDBe:6raw, PDBj:6raw
PDBsum6raw
PubMed31484077
UniProtQ9VGW6|MCM5_DROME DNA replication licensing factor Mcm5 (Gene Name=Mcm5)

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