Structure of PDB 8h6j Chain 4T

Receptor sequence
>8h6j4T (length=456) Species: 9606 (Homo sapiens) [Search protein sequence]
RRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLK
SHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTK
QQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPL
RNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEM
LQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVF
QGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP
LYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPY
LIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDL
IANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYI
QIWKRR
3D structure
PDB8h6j Atomic structures of human exon-defined spliceosome prior to activation.
Chain4T
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 4T C136 H155 H161 C37 H56 H62
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016579 protein deubiquitination
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6j, PDBe:8h6j, PDBj:8h6j
PDBsum8h6j
PubMed38658629
UniProtQ53GS9|UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (Gene Name=USP39)

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