Structure of PDB 8h6k Chain 4K

Receptor sequence
>8h6k4K (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
KDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENK
RENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE
LRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDH
FNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAW
3D structure
PDB8h6k Structural Insights into Human Exon-defined Spliceosome Prior to Activation.
Chain4K
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 4K Y335 F337 K340 Y341 K381 Y391 H393 L394 V395 Y117 F119 K122 Y123 K163 Y173 H175 L176 V177
BS02 rna 4K R385 S386 R388 T389 K390 R167 S168 R170 T171 K172
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0001527 microfibril
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005813 centrosome
GO:0071005 U2-type precatalytic spliceosome

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Cellular Component
External links
PDB RCSB:8h6k, PDBe:8h6k, PDBj:8h6k
PDBsum8h6k
PubMed38658629
UniProtP55081|MFAP1_HUMAN Microfibrillar-associated protein 1 (Gene Name=MFAP1)

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