Structure of PDB 8h6j Chain 4B

Receptor sequence
>8h6j4B (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
PEIEWWDSYIIFGITNLVEHPAQLNPPGVYLTKKEQKKLRRQTRREAQKE
LQEKVRLGLMPPPEPKVISQGVHISVYRVRNLSNPAKKFKIEANAGQLYL
TGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDTNKCVLVWEGTAKD
RSFGEMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLESTD
3D structure
PDB8h6j Atomic structures of human exon-defined spliceosome prior to activation.
Chain4B
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 4B A562 N563 A93 N94
BS02 rna 4B Q445 R449 Q36 R40
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0032991 protein-containing complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8h6j, PDBe:8h6j, PDBj:8h6j
PDBsum8h6j
PubMed38658629
UniProtO43395|PRPF3_HUMAN U4/U6 small nuclear ribonucleoprotein Prp3 (Gene Name=PRPF3)

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