Structure of PDB 8ugh Chain 4A

Receptor sequence

>8ugh4A (length=514) Species: 9823 (Sus scrofa) [Search protein sequence]

MFVNRWLYSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGD
DQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTV
GGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLF
SGYTLNQAWAKIHFVIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTAW
NTISSMGSFISLTAVMLMIFIIWEAFASKREVSAVELTSTNLEWLHGCPP
PYHTFEEPTYINLK

3D structure

PDB

8ugh High-resolution in situ structures of mammalian respiratory supercomplexes.

Chain

Resolution

2.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEA	4A	T31 S34 R38 Y54 V58 H61 A62 M65 M69 W126 Y371 V374 F377 H378 L381 S382 V386 I389 M390 M417 F425 Q428 R439 V465	T31 S34 R38 Y54 V58 H61 A62 M65 M69 W126 Y371 V374 F377 H378 L381 S382 V386 I389 M390 M417 F425 Q428 R439 V465
BS02	HEA	4A	W236 V243 Y244 H290 H291 G317 G352 G355 I356 L358 A359 D364 H368 V373 H376 F377 V380 L381 R438	W236 V243 Y244 H290 H291 G317 G352 G355 I356 L358 A359 D364 H368 V373 H376 F377 V380 L381 R438
BS03	CU	4A	H240 H290 H291	H240 H290 H291
BS04	MG	4A	H368 D369	H368 D369

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen
GO:0015990	electron transport coupled proton transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045277	respiratory chain complex IV

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8ugh, PDBe:8ugh, PDBj:8ugh
PDBsum	8ugh
PubMed	38811722
UniProt	O79876\|COX1_PIG Cytochrome c oxidase subunit 1 (Gene Name=MT-CO1)

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