Structure of PDB 8jd4 Chain 4

Receptor sequence
>8jd44 (length=756) Species: 9606 (Homo sapiens) [Search protein sequence]
NSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRIN
NDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIRVVGVIGASGSSV
SIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVD
IVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPK
AGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGS
DSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIW
FAEFWEDNFHCKLVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALH
AMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDA
PGRYDIYQYQLRAEYKVIGSWTDHLHLRIERMHWQQLPRSICSLPCQPGE
RKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPI
IKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYV
LLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIY
RIFEISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRF
ARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGTFNEAKPIGFTMY
TTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKV
YIILFH
3D structure
PDB8jd4 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Chain4
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU 4 K74 R78 S157 S159 A180 S181 T182 Y230 D312 S313 K317 K34 R38 S96 S98 A119 S120 T121 Y169 D251 S252 K256
Gene Ontology
Molecular Function
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0008066 glutamate receptor activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0051966 regulation of synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jd4, PDBe:8jd4, PDBj:8jd4
PDBsum8jd4
PubMed37286794
UniProtA0A8V8TRG9;
Q14833|GRM4_HUMAN Metabotropic glutamate receptor 4 (Gene Name=GRM4)

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