Structure of PDB 8bvw Chain 4

Receptor sequence
>8bvw4 (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
RTKRWEGGYERTWEILKEVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCT
LKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKA
VDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYD
LIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTH
HVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAEPGLTLGGYF
CPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYN
GERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIH
3D structure
PDB8bvw Structural basis of transcription reduction by a promoter-proximal +1 nucleosome.
Chain4
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 4 C345 C348 C368 C371 C305 C308 C328 C331
BS02 ZN 4 F331 C360 C382 F291 C320 C342
BS03 ZN 4 C291 C294 C305 C308 C251 C254 C265 C268
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0002031 G protein-coupled receptor internalization
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006351 DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0009411 response to UV
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bvw, PDBe:8bvw, PDBj:8bvw
PDBsum8bvw
PubMed37148879
UniProtQ13888|TF2H2_HUMAN General transcription factor IIH subunit 2 (Gene Name=GTF2H2)

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