Structure of PDB 7pmn Chain 4

Receptor sequence
>7pmn4 (length=595) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEE
LYYIKQLNEMRELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMD
QTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDID
KLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCER
IDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDEL
VDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVDLAK
IREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFRYRGDI
NILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYILVLESGA
LVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSS
ILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRK
MTATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKD
3D structure
PDB7pmn A conserved mechanism for regulating replisome disassembly in eukaryotes.
Chain4
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 4 R449 S597 I605 K658 A659 R276 S385 I393 K438 A439
BS02 dna 4 R449 Q450 R451 L614 R276 Q277 R278 L394
BS03 ZN 4 C349 C352 C371 C376 C176 C179 C198 C203
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pmn, PDBe:7pmn, PDBj:7pmn
PDBsum7pmn
PubMed34700328
UniProtP30665|MCM4_YEAST DNA replication licensing factor MCM4 (Gene Name=MCM4)

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