Structure of PDB 7pfo Chain 4

Receptor sequence
>7pfo4 (length=619) Species: 9606 (Homo sapiens) [Search protein sequence]
LGQKLVIWGTDVNVAACKENFQRFLQRFIDPLTEPLYMQRLGEINVIGEP
FLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEH
QIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQC
QVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQE
SPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVS
NVKSVYKTHIDVIHYRKTDAKSEKRVELLKELSRKPDIYERLASALAPSI
YEHEDIKKGILLQLFGGTRKKFRAEINILLCGDPGTSKSQLLQYVYNLVP
RGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDK
MNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKK
TTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAE
EELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVS
AYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRT
GIVDISILTTGMSATSRKR
3D structure
PDB7pfo Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Chain4
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 4 R404 N580 S582 R248 N402 S404
BS02 dna 4 R404 S406 R248 S250
BS03 ZN 4 C306 C328 C331 C150 C172 C175
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfo, PDBe:7pfo, PDBj:7pfo
PDBsum7pfo
PubMed34694004
UniProtP33991|MCM4_HUMAN DNA replication licensing factor MCM4 (Gene Name=MCM4)

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