Structure of PDB 7p30 Chain 4

Receptor sequence
>7p304 (length=654) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
LRIIWGTNVSIQECTTNFRNFLMSFKYKTDEELYYIKQLNEMRELGTSNL
NLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDY
DLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPD
MKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSF
ADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIEVTGTFRS
IPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVD
HNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGIL
LQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYT
SGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDST
RSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTEN
IDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEHDVLPVE
FLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDSDEKRITATTRQL
ESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDPKTGKIDMN
LVQT
3D structure
PDB7p30 Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase.
Chain4
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 4 K594 K612 K403 K421
BS02 ADP 4 I530 Y531 P570 T572 S573 K574 S575 L724 I339 Y340 P379 T381 S382 K383 S384 L533
BS03 ZN 4 C349 C371 C376 C158 C180 C185
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p30, PDBe:7p30, PDBj:7p30
PDBsum7p30
PubMed34963704
UniProtP30665|MCM4_YEAST DNA replication licensing factor MCM4 (Gene Name=MCM4)

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