Structure of PDB 7nw0 Chain 4

Receptor sequence
>7nw04 (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKL
AVIASHIQESRFLYPGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHT
ETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMN
VIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLW
VFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFS
PICTTCETAFKIS
3D structure
PDB7nw0 Structures of mammalian RNA polymerase II pre-initiation complexes.
Chain4
Resolution6.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 4 C271 C285 C242 C256
BS02 ZN 4 C257 H258 C276 C228 H229 C247
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000438 core TFIIH complex portion of holo TFIIH complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nw0, PDBe:7nw0, PDBj:7nw0
PDBsum7nw0
PubMed33902107
UniProtQ13889|TF2H3_HUMAN General transcription factor IIH subunit 3 (Gene Name=GTF2H3)

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