Structure of PDB 3ja8 Chain 4

Receptor sequence
>3ja84 (length=640) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDERDEELYYIKQLNEMR
ELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLI
VDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLR
STPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSL
IHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIE
VTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKVSDKRLDVDTSTIEQEL
MQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELED
VKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKIT
PRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFD
KMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPN
LPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEH
ISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKATTRQL
ESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYAT
3D structure
PDB3ja8 Structure of the eukaryotic MCM complex at 3.8 angstrom
Chain4
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP 4 I530 Y531 P570 S571 T572 S573 K574 S575 Q576 L724 I345 Y346 P385 S386 T387 S388 K389 S390 Q391 L539
BS02 ADP 4 E650 R701 R796 E465 R516 R598
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ja8, PDBe:3ja8, PDBj:3ja8
PDBsum3ja8
PubMed26222030
UniProtP30665|MCM4_YEAST DNA replication licensing factor MCM4 (Gene Name=MCM4)

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