Structure of PDB 8xxn Chain 3N

Receptor sequence
>8xxn3N (length=447) Species: 9606 (Homo sapiens) [Search protein sequence]
AKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYK
RYTNKYSSQFGGGSQYAYFHEEDESSFQLVDVEVRSDWEVKEEMDFPQLM
KMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTT
DDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDK
RDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRM
GKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGV
MTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSY
KLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQI
NLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTF
3D structure
PDB8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Chain3N
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 3N D84 R212 D81 R132
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0098808 mRNA cap binding
Biological Process
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002191 cap-dependent translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0045727 positive regulation of translation
GO:0075522 IRES-dependent viral translational initiation
GO:0075525 viral translational termination-reinitiation
GO:1902416 positive regulation of mRNA binding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0045202 synapse
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum8xxn
PubMed38641729
UniProtO15371|EIF3D_HUMAN Eukaryotic translation initiation factor 3 subunit D (Gene Name=EIF3D)

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