Structure of PDB 7tgh Chain 3C

Receptor sequence

>7tgh3C (length=426) Species: 5911 (Tetrahymena thermophila)

MEWNKGTYMSTSIKKIVQYFSVMTVSFHDINSLFGFFTFLTIASQLVSGT
MLAFSLVPEPMLIPMVREEEDVEDLYTDDFFWLHERGVDMLFIFSYFHLF
RKIYLNNFEYEQEAAWKSGVFTFLLFQVVVFLGLVLCCTHLSDITLAIAA
NLYDTFFAGKGKFYWWIFTSKELNTDTIIRLAYLHYVLAFFLAYLGLIHG
VDMHYDWKNESSMDGLETEMIWFDEALSNELGAMIEIILIVMIVCFFMYP
EPEALSYEFFMWGDIGFINDVRFLSVAPHWYFRPFMAWLTVCPFHKIGLF
GLIYYFFILFYQPVIHGTNEQNNYTKRNVAFVSFFINRSDIMTPKYHSVE
DNLLHQITFWLFLCSALYVTSYLPYGRFYNRINGNYGTLWSFMYIFFYLG
NSFLRRPLITELYLFNAFVKSKFLKK

3D structure

• PDB: 7tgh Structures of Tetrahymena 's respiratory chain reveal the diversity of eukaryotic core metabolism.
• Chain: 3C
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 1.10.2.2: Transferred entry: 7.1.1.8.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	3C	S55 V57 E69 E70 E73	S55 V57 E69 E70 E73
BS02	peptide	3C	N174 T175 D176 G266	N174 T175 D176 G266
BS03	HEM	3C	S32 G35 T38 F39 H98 K102 A115 W116 G119 H199 M203 D206 K208	S32 G35 T38 F39 H98 K102 A115 W116 G119 H199 M203 D206 K208
BS04	HEM	3C	Q45 G49 T50 L56 R67 F81 H84 V88 V129 G133 H185 Y186 A189	Q45 G49 T50 L56 R67 F81 H84 V88 V129 G133 H185 Y186 A189
BS05	U10	3C	F54 Y183	F54 Y183
BS06	U10	3C	S365 Y386 W390	S365 Y386 W390

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:7tgh, PDBe:7tgh, PDBj:7tgh
• PDBsum: 7tgh
• PubMed: 35357889
• UniProt: Q950Z1