Structure of PDB 8xxn Chain 3B

Receptor sequence
>8xxn3B (length=536) Species: 9606 (Homo sapiens) [Search protein sequence]
ADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKT
KGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLDLGNLRYWLEEAEC
RDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATF
HQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQ
AIIIWDILTGHKKRGFHCESSAHWPFKWSHDGKFFARMTLDTLSIYETPS
MGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQE
IRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQ
VPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKIELI
KMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYM
ASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLL
WRPRPPTLLSQEQIKQIKKKIFEQKDRLSQSKASKE
3D structure
PDB8xxn Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.
Chain3B
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 3B K487 D488 K535 G536 Q538 K284 D285 K332 G333 Q335
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0001732 formation of cytoplasmic translation initiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0075522 IRES-dependent viral translational initiation
GO:0075525 viral translational termination-reinitiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0010494 cytoplasmic stress granule
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xxn, PDBe:8xxn, PDBj:8xxn
PDBsum8xxn
PubMed38641729
UniProtP55884|EIF3B_HUMAN Eukaryotic translation initiation factor 3 subunit B (Gene Name=EIF3B)

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