Structure of PDB 5kpx Chain 33

Receptor sequence
>5kpx33 (length=675) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
DPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEI
LSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAQ
VDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNI
YAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEE
FVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRI
VAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGG
KTVEIQIRTKQMHEDAELGVGAAAGGARSGHEDRIAWLRKLIADRVYVFT
PKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQ
IEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQ
ILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFL
QSQFNKPSAEEQDAAALKQLQYTPQNRSKDNGRVVVEGVGNLMHHIARCC
QPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGEGYSL
VVRVVANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIY
NLQVLGRVLGKLNQVPDVIDARRLH
3D structure
PDB5kpx Ribosome•RelA structures reveal the mechanism of stringent response activation.
Chain33
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 33 I440 I448 P450 F451 S472 I380 I388 P390 F391 S412
BS02 rna 33 R611 C612 T626 Q627 R629 S632 Q640 E643 K704 R548 C549 T563 Q564 R566 S569 Q577 E580 K637
BS03 rna 33 K412 D414 Y429 H430 I431 H432 S433 N689 K691 R724 K352 D354 Y369 H370 I371 H372 S373 N622 K624 R657
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008728 GTP diphosphokinase activity
GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016301 kinase activity
Biological Process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0015969 guanosine tetraphosphate metabolic process
GO:0015970 guanosine tetraphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0042594 response to starvation

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Molecular Function
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Biological Process
External links
PDB RCSB:5kpx, PDBe:5kpx, PDBj:5kpx
PDBsum5kpx
PubMed27434674
UniProtP0AG20|RELA_ECOLI GTP pyrophosphokinase (Gene Name=relA)

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