Structure of PDB 5kpw Chain 33

Receptor sequence

>5kpw33 (length=675) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

DPEKWIASLGITSQKSCECLAETWAYCLQQTQGHPDASLLLWRGVEMVEI
LSTLSMDIDTLRAALLFPLADANVVSEDVLRESVGKSVVNLIHGVRDMAQ
VDNVRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNI
YAPLANRLGIGQLKWELEDYCFRYLHPTEYKRIAKLLHERRLDREHYIEE
FVGHLRAEMKAEGVKAEVYGRPKHIYSIWRKMQKKNLAFDELFDVRAVRI
VAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGG
KTVEIQIRTKQMHEDAELGVGAAAGGARSGHEDRIAWLRKLIADRVYVFT
PKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKIGGRIVPFTYQLQMGDQ
IEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQ
ILDDELEHLGISLKEAEKHLLPRYNFNDVDELLAAIGGGDIRLNQMVNFL
QSQFNKPSAEEQDAAALKQLQYTPQNRSKDNGRVVVEGVGNLMHHIARCC
QPIPGDEIVGFITQGRGISVHRADCEQLAELRSHAPERIVDAVWGEGYSL
VVRVVANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIY
NLQVLGRVLGKLNQVPDVIDARRLH

3D structure

PDB

5kpw Ribosome•RelA structures reveal the mechanism of stringent response activation.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.6.5: GTP diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	33	K443 R447 I448 P450 F451	K383 R387 I388 P390 F391
BS02	rna	33	R611 C612 F624 T626 Q627 R629 S632 H634 Q640 E643 R700 T703 K704	R548 C549 F561 T563 Q564 R566 S569 H571 Q577 E580 R633 T636 K637
BS03	rna	33	T410 K412 D414 I431 H432 D434 I463 D550 L553 Q555 N689	T350 K352 D354 I371 H372 D374 I403 D490 L493 Q495 N622

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0008728	GTP diphosphokinase activity
GO:0008893	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
GO:0016301	kinase activity

	Biological Process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0015969	guanosine tetraphosphate metabolic process
GO:0015970	guanosine tetraphosphate biosynthetic process
GO:0016310	phosphorylation
GO:0042594	response to starvation

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:5kpw, PDBe:5kpw, PDBj:5kpw
PDBsum	5kpw
PubMed	27434674
UniProt	P0AG20\|RELA_ECOLI GTP pyrophosphokinase (Gene Name=relA)

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