Structure of PDB 8pw7 Chain 3

Receptor sequence
>8pw73 (length=690) Species: 10090 (Mus musculus) [Search protein sequence]
ASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRM
CLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLD
CPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCI
QCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICP
VGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRM
HEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVA
GMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGA
GTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDL
KVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLG
SSALQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALD
LGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGA
PMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALS
EIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQ
EVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEG
3D structure
PDB8pw7 SCAF1 drives the compositional diversity of mammalian respirasomes.
Chain3
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 3 H101 D104 C105 C108 C114 Q117 V205 H97 D100 C101 C104 C110 Q113 V201
BS02 SF4 3 C153 I154 Q155 C156 T157 R158 C159 V183 C203 P204 L208 C149 I150 Q151 C152 T153 R154 C155 V179 C199 P200 L204
BS03 FES 3 R39 C41 Y42 G50 C52 R53 C55 C69 R35 C37 Y38 G46 C48 R49 C51 C65
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042773 ATP synthesis coupled electron transport
GO:0042776 proton motive force-driven mitochondrial ATP synthesis
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0016020 membrane
GO:0043209 myelin sheath
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pw7, PDBe:8pw7, PDBj:8pw7
PDBsum8pw7
PubMed38575788
UniProtQ91VD9|NDUS1_MOUSE NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (Gene Name=Ndufs1)

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