Structure of PDB 8jd1 Chain 3

Receptor sequence
>8jd13 (length=756) Species: 9606 (Homo sapiens) [Search protein sequence]
RREIKIEGDLVLGGLFPINECGRINEDRGIQRLEAMLFAIDEINKDDYLL
PGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVNIPLLIAGVIGGSYSS
VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMA
EILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNI
RKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDG
WGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFR
DFWEQKFQCSLRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQ
RTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDT
FGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQ
CSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTAD
LTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVK
ASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSA
LLTKTNKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRE
TVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFT
MYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVH
IILFQP
3D structure
PDB8jd1 Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Chain3
Resolution3.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU 3 R64 R68 S149 Y150 S151 A172 Y222 D301 R28 R32 S97 Y98 S99 A120 Y170 D249
BS02 CLR 3 V639 P712 V581 P638
BS03 CLR 3 L624 L646 L697 L566 L588 L623
BS04 CLR 3 E613 F620 E555 F562
Gene Ontology
Molecular Function
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0008066 glutamate receptor activity
GO:0044877 protein-containing complex binding
GO:0097110 scaffold protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010467 gene expression
GO:0033554 cellular response to stress
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0099170 postsynaptic modulation of chemical synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
GO:0097449 astrocyte projection
GO:0098978 glutamatergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jd1, PDBe:8jd1, PDBj:8jd1
PDBsum8jd1
PubMed37286794
UniProtA0A8V8TRG9;
Q14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

[Back to BioLiP]