Structure of PDB 8iuh Chain 3

Receptor sequence
>8iuh3 (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
VSGSGGCNFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPAADS
DREDAAVARDLDCSLEAAAELRAVCGLDKLKEVIPENTDLVTLGVRKRFL
EHREETITIDRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNIL
YPVIFHKHKEHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQ
APEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGK
FQTARMEDFTFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDR
TLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRML
HYDSEGNKLGEFLAYPYVDPGTFN
3D structure
PDB8iuh Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Chain3
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 3 T143 I144 H193 K194 W350 T106 I107 H156 K157 W313
BS02 dna 3 I146 R148 H195 K353 I109 R111 H158 K316
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003681 bent DNA binding
GO:0005515 protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0006383 transcription by RNA polymerase III
GO:0009301 snRNA transcription
GO:0042795 snRNA transcription by RNA polymerase II
GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016604 nuclear body
GO:0019185 snRNA-activating protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuh, PDBe:8iuh, PDBj:8iuh
PDBsum8iuh
PubMed37165065
UniProtQ92966|SNPC3_HUMAN snRNA-activating protein complex subunit 3 (Gene Name=SNAPC3)

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