Structure of PDB 8aw3 Chain 3

Receptor sequence
>8aw33 (length=279) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
SMEEVVVPEEPPKLVSALATYVQQERLCTMFLSIANKLLPLKPHACHLKR
IRRSSAVLELLLSVGGPVDSSALKELESAADTTVAVHRVWVPDRAPRSSA
EEWTKWCQIWPFATPKPRVPTQLSECEVGSIQRIFRTVVMPLAKRLRTDE
TLGIAAVLVDPSDGYRVLVSSGEEHALKRGNSAACLGYVSNSGCRKSNRV
VLDHPVTFVLKEVTRYLANGMDMFVSHEPCVMCSMALVHSRVRRVFYCFP
NPVHGGLGSTVSIHAIQELNHHFRVFRCD
3D structure
PDB8aw3 Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3
Chain3
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.33: tRNA(adenine(34)) deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 3 E24 R166 Y277 N331 E25 R118 Y216 N270
BS02 ZN 3 Y236 H252 C294 Y188 H204 C233
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008251 tRNA-specific adenosine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0052717 tRNA-specific adenosine-34 deaminase activity
Biological Process
GO:0002100 tRNA wobble adenosine to inosine editing
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8aw3, PDBe:8aw3, PDBj:8aw3
PDBsum8aw3
PubMed36347890
UniProtQ381Q7

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