Structure of PDB 6zjl Chain 3

Receptor sequence

>6zjl3 (length=754) Species: 274 (Thermus thermophilus)

MVRVKVNDRIVEVPPGTSVMDAVFHAGYDVPLFCSEKHLSPIGACRMCLV
RIGLIQWQPKLAASCVTAVADGMVVDTLSDVVREAQAGMVEFTLLNHPLD
CPTCDKGGACELQDRTVEYGLYEKPLELPVYTRFEFTRRHVDKHHPLSPF
VILDRERCIHCKRCVRYFEEVPGDEVLDFIERGVHTFIGTMDFGLPSGFS
GNITDICPVGALLDLTARFRARNWEMEETPTTCALCPVGCGITADTRSGE
LLRIRAREVPEVNEIWICDAGRFGHEWADQNRLKTPLVRKEGRLVEATWE
EAFLALKEGLKEARGEEVGLYLAHDATLEEGLLASELAKALKTPHLDFQG
RTAAPASLFPPASLEDLLQADFALVLGDPTEEAPILHLRLSEFVRDLKPP
HRYNHGTPFADLQIKERMPRRTDKMALFAPYRAPLMKWAAIHEVHRPGEE
REILLALLGDKEGSEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERARL
LAERKGAKVLAMTPAANARGLEAMGVLPGAKGASWDEPGALYAYYGFVPP
EEALKGKRFVVMHLSHLHPLAERYAHVVLPAPTFYEKRGHLVNLEGRVLP
LSPAPIENGEAEGALQVLALLAEALGVRPPFRLHLEAQKALKARKVPEAM
GRLSFRLKELRPKERKGAFYLRPTMWKAHQAVGKAQEAARAELWAHPETA
RAEALPEGAQVAVETPFGRVEARVVHREDVPKGHLYLSALGPAAGLRVEG
RVLV

3D structure

• PDB: 6zjl Key role of quinone in the mechanism of respiratory complex I.
• Chain: 3
• Resolution: 4.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): A293 A376 A377 A509 P537 A538
• Catalytic site (residue number reindexed from 1): A270 A353 A354 A486 P514 A515
• Enzyme Commision number: 7.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	3	H115 D118 C119 C122 C128 G233	H97 D100 C101 C104 C110 G210
BS02	SF4	3	C181 I182 C184 C187 C230 L235	C158 I159 C161 C164 C207 L212
BS03	SF4	3	C256 C259 G262 C263 C291 P407 I408	C233 C236 G239 C240 C268 P384 I385
BS04	FES	3	L32 C34 S35 G43 A44 C45 R46 C48 C83	L32 C34 S35 G43 A44 C45 R46 C48 C65

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016491 oxidoreductase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0048038 quinone binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0042773 ATP synthesis coupled electron transport
• GO:0045333 cellular respiration
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6zjl, PDBe:6zjl, PDBj:6zjl
• PDBsum: 6zjl
• PubMed: 32811817
• UniProt: Q56223|NQO3_THET8 NADH-quinone oxidoreductase subunit 3 (Gene Name=nqo3)