Structure of PDB 6xtx Chain 3

Receptor sequence
>6xtx3 (length=608) Species: 9606 (Homo sapiens) [Search protein sequence]
MLPRSPPLPRGNLWELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYR
LIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYE
EFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVH
YCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDH
QTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPG
KKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIF
DQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGD
PSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAG
AMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARC
SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDRE
ISDHVLRMHRYVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQD
SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQY
AYFKKVLE
3D structure
PDB6xtx CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Chain3
Resolution3.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 3 S419 V421 V427 K480 A481 S378 V380 V386 K439 A440
BS02 ADP 3 I352 H353 S393 V394 A395 S397 I311 H312 S352 V353 A354 S356
BS03 AGS 3 A660 R661 E664 A564 R565 E568
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0048471 perinuclear region of cytoplasm
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xtx, PDBe:6xtx, PDBj:6xtx
PDBsum6xtx
PubMed32453425
UniProtP25205|MCM3_HUMAN DNA replication licensing factor MCM3 (Gene Name=MCM3)

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