Structure of PDB 6raz Chain 3

Receptor sequence
>6raz3 (length=590) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
EGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKR
KNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFERHV
TPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTD
LTSFEAVPSGAAYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPLP
RSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGTFRTVLLANNISLLS
KELDISREDIMLCKKLAKNNDIFELLSKSLAPSIGHVKQAILCLLLGGVE
KILPNGTRLRGDINVLLGDPSAKSQLLRYVLNTAPRAIPTTGRGSSGVGL
TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQ
GRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEYEKYDALLHGKSRQRH
EKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVAR
TQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELV
3D structure
PDB6raz Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain3
Resolution4.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 3 A376 E382 A353 E359
BS02 ATP 3 I302 S343 K346 S347 Q348 I284 S321 K323 S324 Q325
BS03 ATP 3 E422 R610 E399 R557
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raz, PDBe:6raz, PDBj:6raz
PDBsum6raz
PubMed31484077
UniProtQ9XYU1|MCM3_DROME DNA replication licensing factor Mcm3 (Gene Name=Mcm3)

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