Structure of PDB 6raw Chain 3

Receptor sequence
>6raw3 (length=585) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
EGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKR
KNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGGN
RHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERK
YTDLTSFEAVPYPTKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQ
LPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGSGTFRTVLLANNI
SLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSLAPSIGHVKQAILCL
LLGGVEKILPNGTRLRGDINVLLGDPSAKSQLLRYVLNTAPRAIPTTGRG
SSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAI
HEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQ
DSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHALLHGKSRQRHEKILSV
EFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITA
RTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQ
3D structure
PDB6raw Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain3
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 3 S369 A375 V377 D380 R387 K430 S352 A358 V360 D363 R370 K413
BS02 ATP 3 I302 A345 K346 S347 I290 A328 K329 S330
BS03 ADP 3 E422 A609 E405 A550
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6raw, PDBe:6raw, PDBj:6raw
PDBsum6raw
PubMed31484077
UniProtQ9XYU1|MCM3_DROME DNA replication licensing factor Mcm3 (Gene Name=Mcm3)

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