Structure of PDB 6q8x Chain 3

Receptor sequence
>6q8x3 (length=756) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MVRVKVNDRIVEVPPGTSVMDAVFHAGYDVPLFCSEKHLSPIGACRMCLV
RIGLPIQWQPKLAASCVTAVADGMVVDTLSDVVREAQAGMVEFTLLNHPL
DCPTCDKGGACELQDRTVEYGLYEKYPLELPVYTRFEFTRRHVDKHHPLS
PFVILDRERCIHCKRCVRYFEEVPGDEVLDFIERGVHTFIGTMDFGLPSG
FSGNITDICPVGALLDLTARFRARNWEMEETPTTCALCPVGCGITADTRS
GELLRIRAREVPEVNEIWICDAGRFGHEWADQNRLKTPLVRKEGRLVEAT
WEEAFLALKEGLKEARGEEVGLYLAHDATLEEGLLASELAKALKTPHLDF
QGRTAAPASLFPPASLEDLLQADFALVLGDPTEEAPILHLRLSEFVRDLK
PPHRYNHGTPFADLQIKERMPRRTDKMALFAPYRAPLMKWAAIHEVHRPG
EEREILLALLGDKEGSEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERA
RLLAERKGAKVLAMTPAANARGLEAMGVLPGAKGASWDEPGALYAYYGFV
PPEEALKGKRFVVMHLSHLHPLAERYAHVVLPAPTFYEKRGHLVNLEGRV
LPLSPAPIENGEAEGALQVLALLAEALGVRPPFRLHLEAQKALKARKVPE
AMGRLSFRLKELRPKERKGAFYLRPTMWKAHQAVGKAQEAARAELWAHPE
TARAEALPEGAQVAVETPFGRVEARVVHREDVPKGHLYLSALGPAAGLRV
EGRVLV
3D structure
PDB6q8x Key role of quinone in the mechanism of respiratory complex I.
Chain3
Resolution3.508 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A293 A376 A377 A509 P537 A538
Catalytic site (residue number reindexed from 1) A272 A355 A356 A488 P516 A517
Enzyme Commision number 7.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 3 H115 D118 C119 C122 C128 Q131 V232 G233 H98 D101 C102 C105 C111 Q114 V211 G212
BS02 SF4 3 C181 C184 C187 C230 C160 C163 C166 C209
BS03 SF4 3 C256 C259 V261 G262 C263 I290 C291 G294 P407 C235 C238 V240 G241 C242 I269 C270 G273 P386
BS04 FES 3 C34 C45 R46 C48 C83 C34 C45 R46 C48 C66
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q8x, PDBe:6q8x, PDBj:6q8x
PDBsum6q8x
PubMed32811817
UniProtQ56223|NQO3_THET8 NADH-quinone oxidoreductase subunit 3 (Gene Name=nqo3)

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