Structure of PDB 6ip6 Chain 2v

Receptor sequence

>6ip62v (length=153) Species: 9606 (Homo sapiens)

ADIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAI
EGTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNR
FEKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGT
KKQ

3D structure

• PDB: 6ip6 HCV IRES Captures an Actively Translating 80S Ribosome.
• Chain: 2v
• Resolution: 4.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2v	E7 F17 K20 Y36 N39 G41 L42 K59 G64 N65 S67 R69 R71 K79 K81 M82 Q83 T85 Y92 H94 R97 K98 K104 R105 H106 K107 N108 R132 P133 L134 S135 K136 T137 R139 F140 Q154	E6 F16 K19 Y35 N38 G40 L41 K58 G63 N64 S66 R68 R70 K78 K80 M81 Q82 T84 Y91 H93 R96 K97 K103 R104 H105 K106 N107 R131 P132 L133 S134 K135 T136 R138 F139 Q153

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ip6, PDBe:6ip6, PDBj:6ip6
• PDBsum: 6ip6
• PubMed: 31080011
• UniProt: P62280|RS11_HUMAN Small ribosomal subunit protein uS17 (Gene Name=RPS11)