Structure of PDB 8vtx Chain 2t

Receptor sequence

>8vtx2t (length=96) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMR
KAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGG

3D structure

PDB

8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2t	L10 A12 K14 R15 H16 R17 Q18 R22 R23 R25 N26 A28 K29 S31 A32 K34 T35 L36 K38 K39 E51 K54 R57 E60 S61 D64 K68 S70 H73 N75 A78 R79 K81 S82 R83 M85 R89 G101 G102 G103	L3 A5 K7 R8 H9 R10 Q11 R15 R16 R18 N19 A21 K22 S24 A25 K27 T28 L29 K31 K32 E44 K47 R50 E53 S54 D57 K61 S63 H66 N68 A71 R72 K74 S75 R76 M78 R82 G94 G95 G96
BS02	MG	2t	A67 K68 G69	A60 K61 G62

External links

PDB	RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum	8vtx
PubMed	39039256
UniProt	P80380\|RS20_THET8 Small ribosomal subunit protein bS20 (Gene Name=rpsT)