Structure of PDB 8vty Chain 2p

Receptor sequence

>8vty2p (length=82) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

MVKIRLARFGSKHNPHYRIVVTDARRKRDGKYIEKIGYYDPRKTTPDWLK
VDVERARYWLSVGAQPTDTARRLLRQAGVFRQ

3D structure

PDB

8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.6 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2p	M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 H16 Y17 R18 D23 A24 R25 K27 R28 G30 K31 Y32 I33 Y38 P41 R42 K43 T44 W59 V62 G63 Q65 T67 T69 R72 R75 F80 Q82	M1 K3 R5 L6 R8 F9 G10 S11 K12 H13 H16 Y17 R18 D23 A24 R25 K27 R28 G30 K31 Y32 I33 Y38 P41 R42 K43 T44 W59 V62 G63 Q65 T67 T69 R72 R75 F80 Q82

External links

PDB	RCSB:8vty, PDBe:8vty, PDBj:8vty
PDBsum	8vty
PubMed	39039256
UniProt	Q5SJH3\|RS16_THET8 Small ribosomal subunit protein bS16 (Gene Name=rpsP)