Structure of PDB 8vtw Chain 2o

Receptor sequence

>8vtw2o (length=88) Species: 300852 (Thermus thermophilus HB8)

PITKEEKQKVIQEFARFPGDTGSTEVQVALLTLRINRLSEHLKVHKKDHH
SHRGLLMMVGQRRRLLRYLQREDPERYRALIEKLGIRG

3D structure

• PDB: 8vtw Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 2o
• Resolution: 2.35 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2o	S40 H53 L56 V60 G89	S39 H52 L55 V59 G88
BS02	rna	2o	P2 K8 Q9 F18 D21 T22 G23 S24 Q28 L31 R35 R38 L39 H42 H46 K48 D49 H50 H51 S52 R54 G55 M58 M59 Q62 R64 R65 Y69	P1 K7 Q8 F17 D20 T21 G22 S23 Q27 L30 R34 R37 L38 H41 H45 K47 D48 H49 H50 S51 R53 G54 M57 M58 Q61 R63 R64 Y68

External links

• PDB: RCSB:8vtw, PDBe:8vtw, PDBj:8vtw
• PDBsum: 8vtw
• PubMed: 39039256
• UniProt: Q5SJ76|RS15_THET8 Small ribosomal subunit protein uS15 (Gene Name=rpsO)