Structure of PDB 8vty Chain 2m

Receptor sequence

>8vty2m (length=114) Species: 300852 (Thermus thermophilus HB8)

RIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAE
VVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQR
TRTNARTRKGPRKT

3D structure

• PDB: 8vty Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
• Chain: 2m
• Resolution: 2.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2m	K13 R14 Y21 Y23 G24 I25 G26 A28 R29 R44 N77 Y87 R88 R91 H92 P97 V98 R99 Q101 R102 T103 R104 T105 N106 R108 T109 R110 K111 R114 K115 T116	K11 R12 Y19 Y21 G22 I23 G24 A26 R27 R42 N75 Y85 R86 R89 H90 P95 V96 R97 Q99 R100 T101 R102 T103 N104 R106 T107 R108 K109 R112 K113 T114

External links

• PDB: RCSB:8vty, PDBe:8vty, PDBj:8vty
• PDBsum: 8vty
• PubMed: 39039256
• UniProt: P80377|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)