Structure of PDB 8vtx Chain 2m

Receptor sequence

>8vtx2m (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

RIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAE
VVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQR
TRTNARTRKGPRKTVAGKKKAP

3D structure

PDB

8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2m	R14 V17 Y21 Y23 G24 I25 G26 A28 R29 R44 N77 Y87 R88 R91 H92 P97 V98 R99 Q101 R102 T103 R104 T105 N106 R108 T109 K111 R114 K115 T116 V117 K120	R12 V15 Y19 Y21 G22 I23 G24 A26 R27 R42 N75 Y85 R86 R89 H90 P95 V96 R97 Q99 R100 T101 R102 T103 N104 R106 T107 K109 R112 K113 T114 V115 K118
BS02	rna	2m	K120 A123	K118 A121
BS03	rna	2m	T116 G119 K121	T114 G117 K119

External links

PDB	RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum	8vtx
PubMed	39039256
UniProt	P80377\|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)