Structure of PDB 8vtv Chain 2m

Receptor sequence

>8vtv2m (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

RIAGVEIPRNKRVDVALTYIYGIGKARAKEALEKTGINPATRVKDLTEAE
VVRLREYVENTWKLEGELRAEVAANIKRLMDIGCYRGLRHRRGLPVRGQR
TRTNARTRKGPRKTVAGKKKAP

3D structure

PDB

8vtv Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.55 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2m	K13 R14 V17 Y21 I22 Y23 G24 I25 G26 R29 R44 V74 N77 R88 R91 H92 P97 V98 R99 Q101 R102 T103 R104 T105 N106 R108 T109 K111 R114 K115 T116 V117 K120	K11 R12 V15 Y19 I20 Y21 G22 I23 G24 R27 R42 V72 N75 R86 R89 H90 P95 V96 R97 Q99 R100 T101 R102 T103 N104 R106 T107 K109 R112 K113 T114 V115 K118
BS02	rna	2m	A118 K121	A116 K119

External links

PDB	RCSB:8vtv, PDBe:8vtv, PDBj:8vtv
PDBsum	8vtv
PubMed	39039256
UniProt	P80377\|RS13_THET8 Small ribosomal subunit protein uS13 (Gene Name=rpsM)