Structure of PDB 8vtu Chain 2l

Receptor sequence

>8vtu2l (length=122) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK

3D structure

PDB

8vtu Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	2l	P5 T6 N8 Q9 L10 R12 R15 E16 P31 F32 R33 R34 K46 K47 N49 S50 L52 R53 T61 Y69 P71 G72 E73 R86 G87 K91 X92 R97 R113 K114 K115 S116 R117 S118 K119 T122 K123 K124	P1 T2 N4 Q5 L6 R8 R11 E12 P27 F28 R29 R30 K42 K43 N45 S46 L48 R49 T57 Y65 P67 G68 E69 R82 G83 K87 X88 R93 R109 K110 K111 S112 R113 S114 K115 T118 K119 K120
BS02	MG	2l	P48 N49	P44 N45
BS03	MG	2l	R97 Y98	R93 Y94
BS04	MG	2l	T67 V96 R97 Y98	T63 V92 R93 Y94

External links

PDB	RCSB:8vtu, PDBe:8vtu, PDBj:8vtu
PDBsum	8vtu
PubMed	39039256
UniProt	Q5SHN3\|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)