Structure of PDB 6xhw Chain 2l

Receptor sequence

>6xhw2l (length=122) Species: 300852 (Thermus thermophilus HB8)

PTINQLVRKGREKVRKKSKVPALKGAPFRRGVCTVVRTVTPKKPNSALRK
VAKVRLTSGYEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGV
YDAAGVKDRKKSRSKYGTKKPK

3D structure

• PDB: 6xhw Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.
• Chain: 2l
• Resolution: 2.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	2l	P5 T6 N8 Q9 L10 R12 R15 E16 A30 P31 F32 R33 R34 K46 K47 P48 N49 S50 L52 R53 K54 T61 Y69 G72 E73 R86 G87 K91 X92 P94 R97 R113 K114 K115 S116 R117 S118 K119 T122 K124	P1 T2 N4 Q5 L6 R8 R11 E12 A26 P27 F28 R29 R30 K42 K43 P44 N45 S46 L48 R49 K50 T57 Y65 G68 E69 R82 G83 K87 X88 P90 R93 R109 K110 K111 S112 R113 S114 K115 T118 K120
BS02	MG	2l	P25 A26 Y64 Y98	P21 A22 Y60 Y94
BS03	MG	2l	R97 Y98	R93 Y94

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xhw, PDBe:6xhw, PDBj:6xhw
• PDBsum: 6xhw
• PubMed: 33462493
• UniProt: Q5SHN3|RS12_THET8 Small ribosomal subunit protein uS12 (Gene Name=rpsL)