Structure of PDB 8vtx Chain 2k

Receptor sequence
>8vtx2k (length=114) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
QVASGRAYIHASYNNTIVTITDPDGNPITWSSGGVIGYKGSRKGTPYAAQ
LAALDAAKKAMAYGMQSVDVIVRGTGAGREQAIRALQASGLQVKSIVDDT
PVPHNGCRPKKKFR
3D structure
PDB8vtx Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Chain2k
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna 2k Y20 H22 N26 N27 I29 T31 G37 N38 P39 I40 W42 S44 G46 G52 S53 K55 R85 P113 V114 H116 N117 G118 C119 R120 K122 K123 Y8 H10 N14 N15 I17 T19 G25 N26 P27 I28 W30 S32 G34 G40 S41 K43 R73 P101 V102 H104 N105 G106 C107 R108 K110 K111
BS02 MG 2k N26 G52 N14 G40
External links
PDB RCSB:8vtx, PDBe:8vtx, PDBj:8vtx
PDBsum8vtx
PubMed39039256
UniProtP80376|RS11_THET8 Small ribosomal subunit protein uS11 (Gene Name=rpsK)

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